体力活动与癫痫患者认知功能的关系：系统评价。
The relationship between physical activity and cognitive function in people with epilepsy: A systematic review.
机构信息
Wake Forest University School of Medicine, Department of Neurology, Winston-Salem, NC, USA.
University of Alabama at Birmingham, Departments of Neurology and Neurobiology, Birmingham, AL, USA.
出版信息
Epilepsy Behav. 2023 May;142:109170. doi: 10.1016/j.yebeh.2023.109170. Epub 2023 Mar 20.
BACKGROUND
This study aimed to systematically review the published literature evaluating the association between physical activity and cognitive function in people with epilepsy (PWE).
METHODS
A comprehensive search of PubMed, Cochrane, Embase, and PsychInfo was performed on June 20, 2022. Studies were excluded if they were not available in the English language, contained animal data only, did not include any original data, were not peer-reviewed, or did not include PWE as a discrete group. PRISMA guidelines were followed. The GRADE scale was used to assess the risk of bias.
RESULTS
Six studies were identified with a total of 123 participants. These included one observational study and five interventional studies, only one of which was a randomized controlled trial. In all studies, there was a positive association between physical activity and cognitive function in PWE. Both interventional studies showed improvement in at least one domain of cognitive functioning, though there was heterogeneity in the outcome measures used.
CONCLUSIONS
There is a potential positive association between physical activity and cognitive function in PWE, but available data is limited by heterogeneity, small sample size, and an overall lack of published studies in this area of research. There is a need for more robust studies to be performed in larger samples of PWE.
背景
本研究旨在系统回顾评估癫痫患者（PWE）体力活动与认知功能之间关联的已发表文献。
方法
于 2022 年 6 月 20 日在 PubMed、Cochrane、Embase 和 PsychInfo 上进行了全面检索。如果文献为非英文文献、仅包含动物数据、未包含任何原始数据、非同行评审或未将 PWE 作为离散组进行研究，则将其排除。研究遵循 PRISMA 指南。使用 GRADE 量表评估偏倚风险。
结果
共确定了 6 项研究，总计 123 名参与者。这些研究包括 1 项观察性研究和 5 项干预性研究，其中仅有 1 项为随机对照试验。在所有研究中，PWE 的体力活动与认知功能之间存在正相关。两项干预性研究均显示认知功能至少有一个领域得到改善，尽管使用的结果测量指标存在异质性。
结论
PWE 中体力活动与认知功能之间可能存在正相关，但现有数据受到异质性、样本量小以及该研究领域缺乏发表研究的限制。需要在更大的 PWE 样本中进行更有力的研究。
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