Di Daniele Nicola, Carbonelli Maria Grazia, Candeloro Nicola, Iacopino Leonardo, De Lorenzo Antonino, Andreoli Angela
Human Nutrition Unit, Via Montpellier 1, University of Rome, "Tor Vergata", 00173 Rome, Italy.
Pharmacol Res. 2004 Dec;50(6):637-41. doi: 10.1016/j.phrs.2004.05.010.
Osteoporosis is a serious global health problem for the future, that is why improving diagnostic methods and prevention of this disease could be helpful.
To assess the effects of calcium supplementations combined with Vitamin D on bone mineral density (BMD) and bone mineral content (BMC) in a representative sample of peri- and post-menopausal women in a double-blind, a randomized, controlled trial was untaken.
A total of 120 women aged over 45 were included in a randomised placebo-controlled, double-blind trial on the effect of a daily dietary supplementation of calcium and Vitamin D on bone mineral density and bone mineral content; over a 30-month period.
Dietary intake assessment; dual-energy X-ray absorptiometry to measure total body and segmental bone mineral density and bone mineral content at beginning of the study and every 15 months were undertaken.
There was no significant change in dietary calcium or Vitamin D intakes in either of the treatment groups during the 30-month intervention period. The change in total BMD in the calcium group was significantly different from that in the placebo group (P <0.005). The placebo group lost a total BMD at a rate of about 0.4% per year. There was an inverse correlation between BMD and age.
The effect of calcium and Vitamin D supplementation on bone mineral density of calcium has been demonstrated in this group of young adult women. Our results showed the positive effect of calcium and Vitamin D supplementation in women both peri- and post-menopausal status; for this reason a supplementation of calcium and Vitamin D should be recommended as a strategic option in helping to prevent early postmenopausal bone loss.
骨质疏松症是未来一个严重的全球性健康问题，这就是为何改进该疾病的诊断方法和预防措施会有所帮助。
在一项双盲、随机对照试验中，评估补充钙联合维生素D对围绝经期和绝经后女性代表性样本的骨密度（BMD）和骨矿物质含量（BMC）的影响。
共有120名45岁以上的女性被纳入一项关于每日膳食补充钙和维生素D对骨密度和骨矿物质含量影响的随机安慰剂对照双盲试验；为期30个月。
进行膳食摄入评估；在研究开始时以及每15个月使用双能X线吸收法测量全身和各部位的骨密度及骨矿物质含量。
在30个月的干预期内，两个治疗组的膳食钙或维生素D摄入量均无显著变化。钙组的总骨密度变化与安慰剂组有显著差异（P<0.005）。安慰剂组的总骨密度以每年约0.4%的速率下降。骨密度与年龄呈负相关。
在这组年轻成年女性中已证实补充钙和维生素D对骨密度有影响。我们的结果显示补充钙和维生素D对处于围绝经期和绝经后状态的女性均有积极作用；因此，应推荐补充钙和维生素D作为帮助预防绝经后早期骨质流失的一项策略选择。
