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骨质疏松症患者股骨近端骨折的治疗策略

Treatment strategies for proximal femur fractures in osteoporotic patients.

作者信息

Bonnaire Felix, Zenker Henry, Lill Christoph, Weber Andreas T, Linke Berend

机构信息

Department of Trauma Surgery, Dresden-Friedrichstadt Hospital, Germany.

出版信息

Osteoporos Int. 2005 Mar;16 Suppl 2:S93-S102. doi: 10.1007/s00198-004-1746-7. Epub 2004 Oct 16.

Abstract

Fractures of the proximal end of the femur, together with vertebral fractures, are greatly exacerbated by osteoporosis and can be regarded as the most typical and most serious complications of this disease. The demand for prompt mobilisation with full loading of the affected limb, combined with a desire for the gentlest of treatments, becomes increasingly difficult to meet in ageing patients with advanced osteoporosis. The advantages of osteosynthesis in respect to these demands when operating on elderly patients with fractures do not apply due to the inability of the osteoporotic bone to hold the osteosynthetic components sufficiently until fracture healing occurs. This inability is related to the anatomy of the proximal end of the femur and its loading patterns. Under eccentric loading, high bending loads occur, leading to failure of the osteosynthetic anchorage at the center of the femoral head. This leads subsequently to stressful revision operations for the patient. The prosthetic replacement is a good option in cases of dislocated intracapsular fractures, but in cases of trochanteric fractures it is still debated. Therefore, it is vital for the trauma surgeon to have specific knowledge of the patient's bone quality in order to optimise the result of the preferred procedure. With reference to our own experimental research and a study of the current literature, this knowledge can be summarised as follows: the most stable anchorage for the implant is achieved by placing the implant through the midpoint of the femoral head (highest bone mineral density) or just below ("best backing"). Anchoring femoral head implants so that they are stable in rotation within the head-neck fragment will significantly raise their load bearing capacity. This is also true for intramedullary load bearing devices in trochanteric fractures. The distance between the load-bearing device in the femoral neck and the articular surface is inversely correlated to the stability at yield, as other studies have already shown. There seems to be a limit for a successful realisation of an osteosynthesis that lies at a femoral head bone mineral density of 250 mg/cm(3) calcium-hydroxyapatite (CaHAp). Nevertheless, high precision surgery in regard to fracture reduction and implant placement is a essential requirement for a successful osteosynthesis. Reproducible local measurements of bone mineral density and trabecular alterations, as well as quick screening methods, are very much desired by the authors.

摘要

股骨近端骨折与椎体骨折一样,因骨质疏松而大大加重,可被视为该疾病最典型、最严重的并发症。对于患有晚期骨质疏松症的老年患者而言,既要迅速让患肢完全负重活动,又希望采用最温和的治疗方法,这两者之间的需求越来越难以兼顾。在对老年骨折患者进行手术时,鉴于骨质疏松的骨骼在骨折愈合前无法充分固定骨合成部件,骨合成在满足上述需求方面的优势无法体现。这种无能为力与股骨近端的解剖结构及其负荷模式有关。在偏心负荷作用下,会产生高弯曲负荷,导致股骨头中心的骨合成锚固失效。这随后会给患者带来压力巨大的翻修手术。对于囊内脱位骨折,假体置换是个不错的选择,但对于转子间骨折,仍存在争议。因此,创伤外科医生了解患者的骨质情况至关重要,以便优化首选手术的效果。参照我们自己的实验研究以及对当前文献的研究,这些知识可总结如下:将植入物置于股骨头中点(骨矿物质密度最高)或其下方(“最佳支撑”)可实现植入物最稳定的锚固。固定股骨头植入物,使其在头颈碎片内旋转稳定,将显著提高其承重能力。对于转子间骨折的髓内承重装置也是如此。正如其他研究已经表明的,股骨颈承重装置与关节面之间的距离与屈服时的稳定性呈负相关。对于骨合成的成功实现,似乎存在一个限度,即股骨头骨矿物质密度为250毫克/立方厘米羟基磷灰石(CaHAp)。然而,骨折复位和植入物放置方面的高精度手术是成功进行骨合成的基本要求。作者非常希望能有可重复的局部骨矿物质密度测量和小梁改变测量方法,以及快速筛查方法。

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