Kuhn J H, Seregin S V, Morzunov S P, Petrova I D, Vyshemirskii O I, Lvov D K, Tyunnikov G I, Gutorov V V, Netesov S V, Petrov V S
Charité - Universitätsmedizin Berlin, Institut für Infektionsmedizin, Berlin, Germany.
Arch Virol. 2004 Nov;149(11):2199-213. doi: 10.1007/s00705-004-0354-3. Epub 2004 Jun 15.
Crimean-Congo hemorrhagic fever (CCHF) is a severe zoonosis with a high fatality rate. In Russia, local CCHF outbreaks have occurred in the Stavropol Territory, and the Volgograd and Astrakhan Regions during 2000 and 2001. Seven strains of CCHF virus (CCHFV) were isolated from infected patients and collected ticks. Two fragments of the CCHF virus M genome segment were PCR amplified and their nucleotide sequences were determined. All these virus strains appear to be closely related (up to 5.8% nucleotide sequence differences) and form a distinct clade on the CCHFV phylogenetic tree. Within this clade, CCHFV strains from Stavropol and Astrakhan cluster together, whereas those from Volgograd form a separate subgroup.
克里米亚-刚果出血热（CCHF）是一种病死率很高的严重人畜共患病。在俄罗斯，2000年至2001年期间，斯塔夫罗波尔边疆区、伏尔加格勒州和阿斯特拉罕州均发生了局部CCHF疫情。从感染患者和采集的蜱虫中分离出7株CCHF病毒（CCHFV）。对CCHF病毒M基因组片段的两个片段进行了PCR扩增，并测定了其核苷酸序列。所有这些病毒株似乎密切相关（核苷酸序列差异高达5.8%），并在CCHFV系统发育树上形成一个独特的分支。在这个分支内，来自斯塔夫罗波尔和阿斯特拉罕的CCHFV株聚集在一起，而来自伏尔加格勒的病毒株则形成一个单独的亚组。
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