Nicholson Daniel A, Freeman John H
Department of Psychology, University of Iowa, IA, USA.
Behav Neurosci. 2004 Oct;118(5):1111-6. doi: 10.1037/0735-7044.118.5.1111.
Previous studies have demonstrated that learning-related cerebellar plasticity and stimulus-elicited neuronal activity emerge ontogenetically in parallel with delay eyeblink conditioning in rats. The present study examined cerebellar interpositus field potentials and multiunit neuronal activity evoked by microstimulation of the inferior olive in Postnatal Day 17 and 24 rats. The slope and amplitude of the excitatory postsynaptic potential and the number of evoked multiunit spikes increased with age, whereas the inhibitory postsynaptic potential caused by Purkinje cell input remained stable. These results are consistent with the notion that the postsynaptic depolarization of cerebellar interpositus neurons caused by cerebellar afferents (e.g., the climbing fibers of the inferior olive) is a critical factor contributing to the ontogeny of delay eyeblink conditioning in rats.
先前的研究表明,与学习相关的小脑可塑性和刺激诱发的神经元活动在大鼠中与延迟眨眼条件反射在个体发育过程中并行出现。本研究检测了出生后第17天和第24天大鼠小脑间位核的场电位以及由下橄榄核微刺激诱发的多单位神经元活动。兴奋性突触后电位的斜率和幅度以及诱发的多单位峰电位数量随年龄增加,而浦肯野细胞输入引起的抑制性突触后电位保持稳定。这些结果与以下观点一致,即小脑传入纤维(例如下橄榄核的攀缘纤维)引起的小脑间位核神经元的突触后去极化是大鼠延迟眨眼条件反射个体发育的关键因素。