Gibas Z, Miettinen M, Sandberg A A
Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Cancer Genet Cytogenet. 1992 Feb;58(2):169-73. doi: 10.1016/0165-4608(92)90106-i.
Cytogenetic analyses of two sacral chordomas are reported. Both tumors showed clonal chromosome abnormalities, including numerical and structural aberrations. The modal chromosome numbers were 36 and 72, respectively. The hypodiploid tumor had a single structural abnormality identified as a der(21)t(1;21)(q21;q22). The near-triploid tumor had numerous structural rearrangements, including a der(21)t(2;21)(q11;q22), which involves the same band of chromosome 21 as the translocation in the first tumor. Prophasing was a prominent cytogenetic feature of this tumor. The consistent involvement of band 21q22 in translocations in two chordomas suggests a possible specific association of this chromosome region with chordoma. Protooncogenes ETS2 and ERG have been mapped to this chromosome band.
报道了两例骶骨脊索瘤的细胞遗传学分析。这两个肿瘤均显示出克隆性染色体异常，包括数目和结构畸变。众数染色体数分别为36和72。亚二倍体肿瘤有一个单一的结构异常，鉴定为der(21)t(1;21)(q21;q22)。近三倍体肿瘤有许多结构重排，包括der(21)t(2;21)(q11;q22)，它涉及与第一个肿瘤中的易位相同的21号染色体带。前期是该肿瘤突出的细胞遗传学特征。两例脊索瘤中21q22带在易位中持续受累，提示该染色体区域与脊索瘤可能存在特定关联。原癌基因ETS2和ERG已定位到该染色体带。
