Tihy F, Scott P, Russo P, Champagne M, Tabet J C, Lemieux N
Département de Pathologie, Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal, Québec, Canada.
Cancer Genet Cytogenet. 1998 Aug;105(1):14-9. doi: 10.1016/s0165-4608(97)00481-0.
We report the cytogenetic and histopathological findings in a 7-year-old female child with an intranasal tumor that is most consistent with a parachordoma. Karyotypic analysis of the tumor revealed clonal numerical and structural chromosome abnormalities. Seven cells displayed recurrent changes: der(2)t(2;4), del(3q), and the loss of chromosomes 9, 10, 20, and 22. Four cells showed a loss of chromosome 17. To the best of our knowledge, these are the first clonal chromosome abnormalities described in parachordoma.
我们报告了一名7岁女童鼻内肿瘤的细胞遗传学和组织病理学发现，该肿瘤最符合副脊索瘤。对肿瘤进行的核型分析显示出克隆性的染色体数目和结构异常。七个细胞呈现出反复出现的变化：der(2)t(2;4)、del(3q)，以及9号、10号、20号和22号染色体缺失。四个细胞显示17号染色体缺失。据我们所知，这些是副脊索瘤中首次描述的克隆性染色体异常。
