Bocheńska-Marciniak Małgorzata, Górski Paweł
Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej UM w Lodzi.
Pol Merkur Lekarski. 2004 Jun;16(96):527-31.
The aim of this study was to determine the prevalence of gastroesophageal reflux disease (GERD) in patient with asthma, its relation to the severity of asthma, BMI (body mass index) and method of treatment. Two hundred eight patients with asthma were included in the study. All patients were carefully studied for asthma severity and surveyed using questionnaire specific for diagnosis of GERD also BMI was determined. Among the asthmatics 22.1% had chronic severe asthma, 43.3% had chronic moderate asthma and 34.6% had chronic mild asthma. GERD was present in 86.9% of patients with severe asthma (p<0.001 as compared to moderate and mild asthma), 62.2% of patients with moderate asthma and 48.6% of patients with mild asthma. BMI was significantly higher in patients with severe asthma and reached 28+/-5.3 kg/m2. GERD was present in all patients with severe asthma and BMI above 30 kg/m2. 72.5%, 17.85% and 8.6% of patients with severe, moderate and mild asthma respectively, experienced symptoms of GERD after ingestion of theophylline and oral steroids. The study demonstrated a greater prevalence of GERD symptoms in severe asthma and related GERD to BMI and treatment with theophylline and systemic steroids.
本研究的目的是确定哮喘患者中胃食管反流病（GERD）的患病率、其与哮喘严重程度、体重指数（BMI）及治疗方法的关系。本研究纳入了280例哮喘患者。对所有患者的哮喘严重程度进行了仔细研究，并使用专门用于GERD诊断的问卷进行了调查，同时还测定了BMI。在哮喘患者中，22.1%患有慢性重度哮喘，43.3%患有慢性中度哮喘，34.6%患有慢性轻度哮喘。重度哮喘患者中86.9%存在GERD（与中度和轻度哮喘相比，p<0.001），中度哮喘患者中62.2%存在GERD，轻度哮喘患者中48.6%存在GERD。重度哮喘患者的BMI显著更高，达到28±5.3kg/m²。所有重度哮喘且BMI高于30kg/m²的患者均存在GERD。重度、中度和轻度哮喘患者分别有72.5%、17.85%和8.6%在摄入茶碱和口服类固醇后出现GERD症状。该研究表明重度哮喘中GERD症状的患病率更高，且GERD与BMI以及茶碱和全身类固醇治疗有关。
