Takenaka R, Matsuno O, Kitajima K, Ono E, Hiroshige S, Nishitake T, Miyazaki E, Kumamoto T
Division of Respiratory Disease and Neurology, Third Department of Internal Medicine, Oita University Faculty of Medicine, Idaigaoka 1-1, Hasama-machi, Oita 879-5593, Japan.
Allergol Immunopathol (Madr). 2010 Jan-Feb;38(1):20-4. doi: 10.1016/j.aller.2009.06.005. Epub 2010 Jan 25.
In adult asthmatics the incidence of gastro-oesophageal reflux disease (GERD) reportedly ranges from 34% to 89%. Oesophageal pH monitoring and endoscopy are not required in the patient with typical GERD symptoms before the initiation of a therapeutic trial. Diagnosis of GERD on the basis of history is the simplest and quickest method, placing no demand on patients. Recently, a new questionnaire (FSSG; Frequency Scale for the Symptoms of GERD) was produced to evaluate the severity and the therapeutic response of GERD. The FSSG (F-scale) was used to assess the GERD in subjects with persistent moderate to severe asthma treated with anti-inflammatory asthma medication. In the present study, 27.4% of the patients with asthma had symptoms suggestive of GERD. There is significant correlation between GERD symptom (F-scale score) and severity of cough and sputum. The observations suggested that reflux symptoms, not gastric dysmotility symptoms, significantly associated with severity of cough, not of sputum. It is the first such study to use a FSSG as incidence of GERD symptoms in asthmatics and examine the relationship between F-scale score and asthmatic symptoms.
据报道，成年哮喘患者中胃食管反流病（GERD）的发病率在34%至89%之间。在开始治疗试验之前，有典型GERD症状的患者无需进行食管pH监测和内镜检查。基于病史诊断GERD是最简单、最快捷的方法，对患者没有要求。最近，一种新的问卷（FSSG；胃食管反流病症状频率量表）被制作出来，用于评估GERD的严重程度和治疗反应。FSSG（F量表）用于评估接受抗炎哮喘药物治疗的持续性中度至重度哮喘患者的GERD情况。在本研究中，27.4%的哮喘患者有提示GERD的症状。GERD症状（F量表评分）与咳嗽和咳痰的严重程度之间存在显著相关性。观察结果表明，反流症状而非胃动力障碍症状与咳嗽严重程度显著相关，而非与咳痰严重程度相关。这是第一项使用FSSG作为哮喘患者GERD症状发生率并研究F量表评分与哮喘症状之间关系的此类研究。
