Anastasiadis P, Anninos P, Diamantopoulos P, Sivridis E
Democritus University of Thrace, Alexandroupolis, Greece.
J Obstet Gynaecol. 1997 Mar;17(2):123-6. doi: 10.1080/01443619750113627.
This study investigates the fetal brain activity in normal and pre-eclamptic pregnancies. Measurements were performed by means of a superconducting quantum interference device (SQUID) in an electrically shielded room of low magnetic noise. The study was prospective. Ten pregnant women with pre-eclampsia and 11 healthy gravidae were included. All were preterm at 28 to 37 weeks' gestation. Biomagnetic signals (waveforms), recorded from the fetal brains in the frequencies 2-7 Hz, were expressed in terms of magnetic power spectral amplitudes: these were low in almost all normal pregnancies, and high in most pregnancies complicated with pre-eclampsia. The pictorial representation of the results in the form of iso-spectral amplitude (ISO-SA) mapping showed two different patterns: (a) iso-contour lines 'organised' in dense concentration zones (pre-eclamptic pattern), (b) iso-contour lines at random distribution without dense concentration zones (normal pattern). Biomagnetic measurements of fetal brain activity is a promising screening procedure for assessing the cerebral function, especially at high risk pregnancies.
本研究调查了正常妊娠和子痫前期妊娠中的胎儿脑活动。测量是在低磁噪声的电屏蔽室内通过超导量子干涉装置（SQUID）进行的。该研究是前瞻性的。纳入了10名单纯收缩期高血压孕妇和11名健康孕妇。所有孕妇均为妊娠28至37周的早产孕妇。从胎儿大脑记录的2-7Hz频率的生物磁信号（波形），以磁功率谱幅度表示：几乎所有正常妊娠中这些信号较低，而在大多数子痫前期妊娠中较高。结果以等谱振幅（ISO-SA）映射形式的图形表示显示出两种不同模式：（a）等轮廓线在密集集中区域“组织化”（子痫前期模式），（b）等轮廓线随机分布且无密集集中区域（正常模式）。胎儿脑活动的生物磁测量是评估脑功能，尤其是高危妊娠脑功能的一种有前景的筛查方法。
