Sowunmi A, Oduola A M, Ogundahunsi O A, Fehintola F A, Ilesanmi O A, Akinyinka O O, Arowojolu A O
University of Ibadan, Nigeria.
J Obstet Gynaecol. 1998 Jul;18(4):322-7. doi: 10.1080/01443619867038.
The efficacy of artemether and artemether followed by mefloquine was evaluated in 45 pregnant women with drug resistant Plasmodium falciparum malaria during the second and third trimesters. There was prompt clinical response to both treatment regimens. The parasite and fever clearance times and the cure rate were similar in both groups. Except for the correlation between initial parasite density and fever clearance time in the artemether-mefloquine group, there was no correlation between initial parasite density and parasite or fever clearance times in the two groups. Similarly, there was no correlation between parasite and fever clearance. Both treatment regimens were well tolerated. All newborn babies of the participating women were normal at birth. Physical and neurodevelopmental assessment of the newborn babies followed up for a period varying between 6 and 36 months were within normal limits. Artemether alone or with mefloquine are effective and do not produce undue deleterious effects in pregnant patients with drug-resistant falciparum malaria during the second and third trimesters.
对45名在妊娠中期和晚期感染耐多药恶性疟原虫疟疾的孕妇，评估了青蒿醚以及青蒿醚加甲氟喹的疗效。两种治疗方案均带来了迅速的临床反应。两组的寄生虫清除时间、发热消退时间及治愈率相似。除青蒿醚-甲氟喹组初始寄生虫密度与发热消退时间之间存在相关性外，两组的初始寄生虫密度与寄生虫清除时间或发热消退时间之间均无相关性。同样，寄生虫清除与发热消退之间也无相关性。两种治疗方案耐受性均良好。参与研究的女性所生的所有新生儿出生时均正常。对随访6至36个月的新生儿进行的体格和神经发育评估均在正常范围内。单独使用青蒿醚或与甲氟喹联用，对妊娠中期和晚期感染耐多药恶性疟原虫疟疾的孕妇有效，且不会产生过度有害影响。
