慢传输型便秘患者结肠切除术后的肽YY释放情况。
Peptide YY release after colectomy in slow transit constipation.
作者信息
Hopman W P M, Mollen R M H G, Kuijpers J H C, Jansen J B M J
机构信息
Dept. of Gastroenterology and Hepatology, University Medical Center Nijmegen, Nijmegen, The Netherlands.
出版信息
Scand J Gastroenterol. 2004 Aug;39(8):727-30. doi: 10.1080/00365520410006260.
BACKGROUND
The gut hormone peptide YY is abundant in the colonic mucosa. Circulating PYY inhibits gastrointestinal motility and decreases food intake. The aim was to determine whether colectomy decreases PYY release in patients with slow transit constipation.
METHODS
Plasma PYY concentrations were measured in 10 patients with slow transit constipation before and 3-24 months after total abdominal colectomy with ileorectal anastomosis, and in 8 healthy controls. A liquid meal was infused intraduodenally to stimulate PYY release.
RESULTS
Postprandial PYY significantly (P < 0.05) increased from a basal value of 15.6 +/- 1.8 pM to a peak of 71.2 +/- 11.6 pM after colectomy. Basal and postprandial plasma PYY concentrations were not significantly different from the results before surgery. Fasting, but not postprandial, plasma peptide YY after colectomy was significantly higher than that in healthy volunteers, 10.9 +/- 0.9 pM.
CONCLUSION
Despite removal of a major source of PYY-secreting cells, colectomy with ileorectal anastomosis does not induce major impairment of PYY release in slow transit constipation.
背景
肠道激素肽YY在结肠黏膜中含量丰富。循环中的PYY抑制胃肠蠕动并减少食物摄入。目的是确定结肠切除术是否会降低慢传输型便秘患者的PYY释放。
方法
测量了10例慢传输型便秘患者在全腹结肠切除回直肠吻合术前以及术后3 - 24个月时的血浆PYY浓度，并与8名健康对照者进行比较。通过十二指肠内注入流食来刺激PYY释放。
结果
结肠切除术后，餐后PYY从基础值15.6±1.8 pM显著（P < 0.05）增加至峰值71.2±11.6 pM。基础和餐后血浆PYY浓度与手术前结果无显著差异。结肠切除术后空腹时的血浆肽YY（10.9±0.9 pM）显著高于健康志愿者，但餐后无此差异。
结论
尽管去除了分泌PYY细胞的主要来源，但回直肠吻合术式的结肠切除术不会导致慢传输型便秘患者的PYY释放出现重大损害。
Zotero 插件