van den Bergh H
Swiss Federal Institute of Technology, Lausanne, Switzerland.
Semin Ophthalmol. 2001 Dec;16(4):181-200. doi: 10.1076/soph.16.4.181.10299.
We briefly review the history and principles of photodynamic therapy (PDT), especially as it is applied to choroidal neovascularization (CNV) in age-related macular degeneration (AMD). After a brief general history of PDT, we discuss the relationship between the physicochemical structure and photodynamic activity of the second-generation photosensitizers, such as those in current clinical use. We then discuss the basic photophysics of photosensitizer molecules, and describe the initial chemical reactions induced by activated sensitizers. We outline a novel method for screening photosensitizers to be used in treating CNV, as well as the complex biomolecular pathways modulated by PDT-induced oxidative stress and the vascular effects of PDT in solid tumors. The paper closes with a discussion of how all this information might be used to improve the selectivity and efficacy of clinically useful photosensitizers.
我们简要回顾光动力疗法（PDT）的历史和原理，特别是其应用于年龄相关性黄斑变性（AMD）中的脉络膜新生血管（CNV）的情况。在简要介绍PDT的一般历史之后，我们讨论第二代光敏剂（如目前临床使用的光敏剂）的物理化学结构与光动力活性之间的关系。接着，我们讨论光敏剂分子的基本光物理学，并描述活化敏化剂引发的初始化学反应。我们概述了一种筛选用于治疗CNV的光敏剂的新方法，以及PDT诱导的氧化应激所调节的复杂生物分子途径和PDT对实体瘤的血管效应。本文最后讨论了如何利用所有这些信息来提高临床有用光敏剂的选择性和疗效。
