Altamirano Diego, Martinez Jaime, Leviste Katherine D, Parel Jean Marie, Amescua Guillermo
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ocular Microbiology Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Curr Ophthalmol Rep. 2020 Dec;8:245-251. doi: 10.1007/s40135-020-00252-y. Epub 2020 Sep 12.
Infectious keratitis is a sight-threatening microbial infection. The prevalence of antimicrobial resistance in cases of infectious keratitis has increased the demand for fortified compounded antimicrobial drops. Even with proper medical management, severe cases of infectious keratitis can further evolve into corneal perforation, requiring surgical intervention in the form of keratoplasty to control the infectious process. Due to the invasive nature of the procedure and the shortage of available donor tissue around the world, alternative treatments are needed for the management of progressive infectious keratitis. In ophthalmology, photodynamic therapy (PDT) has been used for numerous applications. PDT with Rose Bengal as a photosensitizer combined with green light optical irradiation (RB-PDAT) is a novel treatment with dual purpose: to arrest the infection from progressing and strengthen the collagen of the cornea. RB-PDAT may be considered as an adjunct therapy in severe cases of infectious keratitis to minimize the need for a therapeutic keratoplasty.
感染性角膜炎是一种威胁视力的微生物感染。感染性角膜炎病例中抗菌药物耐药性的增加，使得对强化复方抗菌滴眼液的需求上升。即使进行适当的药物治疗，严重的感染性角膜炎病例仍可能进一步发展为角膜穿孔，需要通过角膜移植术的手术干预来控制感染过程。由于该手术具有侵入性，且全球可用供体组织短缺，因此需要替代治疗方法来管理进行性感染性角膜炎。在眼科领域，光动力疗法（PDT）已被广泛应用。以孟加拉玫瑰红作为光敏剂并结合绿光光学照射的光动力疗法（RB-PDAT）是一种具有双重目的的新型治疗方法：阻止感染进展并强化角膜的胶原蛋白。RB-PDAT可被视为严重感染性角膜炎病例的辅助治疗方法，以尽量减少治疗性角膜移植术的需求。
