Olsson A Reckner, Skogh T, Wingren G
Division of Occupational and Environmental Medicine, Unit for Autoimmunity and Immune Regulation, Department of Molecular and Clinical Medicine, Linköping University, Sweden.
Scand J Rheumatol. 2004;33(5):300-6. doi: 10.1080/03009740310004748.
To evaluate exposure to external factors associated with risk or prevention of rheumatoid arthritis (RA).
Two hundred and ninety-three incident cases of RA and 1346 population-based referents were included in a case-referent study, in which previous exposure experiences were collected through a postal questionnaire.
An inverse association between RA and additional schooling after compulsory school was seen for men. Current smoking was associated with significantly increased risks of RA for men and women [odds ratio (OR) 2.9, 95% confidence interval (CI) 1.4-6.4, and OR 1.8, 95% CI 1.1-2.9, respectively], as was previous smoking for men (OR 2.3, 95% CI 1.2-4.4). There were also indications of relationships between previous use of a private well and RA in both men and women.
Several previously published associations have been reproduced in the present study, which also generates some new hypotheses that suggest further research.
评估与类风湿关节炎（RA）风险或预防相关的外部因素暴露情况。
一项病例对照研究纳入了293例RA新发病例和1346名基于人群的对照者，通过邮寄问卷收集既往暴露经历。
男性中，RA与义务教育后的额外受教育程度呈负相关。当前吸烟与男性和女性患RA的风险显著增加相关[优势比（OR）分别为2.9，95%置信区间（CI）1.4 - 6.4，以及OR 1.8，95% CI 1.1 - 2.9]，男性既往吸烟情况也是如此（OR 2.3，95% CI 1.2 - 4.4）。还有迹象表明，男性和女性既往使用私人水井的情况与RA之间存在关联。
本研究重现了一些先前发表的关联，同时也产生了一些新的假设，提示需要进一步研究。
