Uhlig T, Hagen K B, Kvien T K
Oslo City Department of Rheumatology, Diakonhjemmet Hospital, Norway.
J Rheumatol. 1999 Jan;26(1):47-54.
To identify if tobacco smoking or sociodemographic characteristics are risk factors of rheumatoid arthritis (RA).
From a county RA register 361 patients in the age range 20-79 years were recruited from incidence cohorts with recent disease onset (mean 3.4 years) and compared with 5851 randomly selected individuals from the same population area. Data on selected risk factors were collected by questionnaires (response rate 75 and 59%, respectively) and associations with smoking and risk factors were expressed as odds ratios (OR) with 95% confidence intervals (CI) in a multiple regression analysis.
Age and female sex were, as expected, identified as risk factors of RA. In addition, current smoking was an overall risk factor (OR 1.46, 95% CI 1.10-1.94), in men (OR 2.38, 95% CI 1.45-3.92), especially in men with seropositive RA (OR 4.77, 95% CI 2.09-10.90). Separate analyses revealed no statistically significant risk in women (OR 1.14, 95% CI 0.80-1.62). Low level of formal education, body mass index, marital or employment status were not significantly associated with risk of RA.
Current smoking in men was identified as an independent risk factor for RA, whereas surrogate markers of socioeconomic status were unrelated to the onset of RA.
确定吸烟或社会人口学特征是否为类风湿关节炎（RA）的危险因素。
从一个县级RA登记处，招募了361名年龄在20 - 79岁之间、近期发病（平均3.4年）的发病队列患者，并与从同一人口区域随机选取的5851名个体进行比较。通过问卷调查收集选定危险因素的数据（回复率分别为75%和59%），在多元回归分析中，将吸烟及危险因素的关联表示为比值比（OR）及95%置信区间（CI）。
正如预期，年龄和女性性别被确定为RA的危险因素。此外，当前吸烟是一个总体危险因素（OR 1.46，95% CI 1.10 - 1.94），在男性中（OR 2.38，95% CI 1.45 - 3.92），尤其是血清阳性RA男性（OR 4.77，95% CI 2.09 - 10.90）。单独分析显示女性无统计学显著风险（OR 1.14，95% CI 0.80 - 1.62）。低水平正规教育、体重指数、婚姻或就业状况与RA风险无显著关联。
男性当前吸烟被确定为RA的独立危险因素，而社会经济地位的替代指标与RA发病无关。
