一名核型为46,XX/46,XY的嵌合型不育男性使用冷冻睾丸精子成功妊娠：病例报告
A successful pregnancy outcome using frozen testicular sperm from a chimeric infertile male with a 46, XX/46, XY karyotype: case report.
作者信息
Sugawara Nobuo, Tokunaga Yo, Maeda Machiko, Komaba Rie, Araki Yasuhisa
机构信息
Iwaki Women's Clinic, 3-2, Ookishita, Uchigo, Iwaki, Fukushima, 973-8403, Japan.
出版信息
Hum Reprod. 2005 Jan;20(1):147-8. doi: 10.1093/humrep/deh587. Epub 2004 Oct 28.
BACKGROUND
We report a very rare case of the successful delivery of a healthy infant fathered by an infertile chimera.
METHODS
ICSI was performed using frozen sperm. The karyotypes of peripheral lymphocytes were examined with a G-banding stain.
RESULTS
Chromosomal analysis prior to ICSI revealed a 46, XX [28]/46, XY [2] karyotype chimera. As an infant, the subject was diagnosed as a true hermaphrodite, and underwent a hysterectomy and oophorectomy. A small number of sperm were found in minced testicular tissue, and they were stored for ICSI.
CONCLUSION
To the best of our knowledge, this is the first case report of a successful pregnancy and delivery of a healthy infant fathered by an infertile chimera (46, XX/46, XY) following ICSI using frozen testicular sperm.
背景
我们报告了一例极为罕见的病例，一名不育嵌合体成功孕育并分娩出一名健康婴儿。
方法
使用冷冻精子进行卵胞浆内单精子注射（ICSI）。采用G显带染色检查外周血淋巴细胞的核型。
结果
ICSI前的染色体分析显示为46, XX [28]/46, XY [2]核型嵌合体。该患者幼时被诊断为真两性畸形，并接受了子宫切除术和卵巢切除术。在切碎的睾丸组织中发现了少量精子，并将其保存用于ICSI。
结论
据我们所知，这是首例关于不育嵌合体（46, XX/46, XY）经冷冻睾丸精子进行ICSI后成功妊娠并分娩出健康婴儿的病例报告。
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