鼠疫耶尔森氏菌f1操纵子中一个参与荚膜生物合成的新基因。
A new gene of the f1 operon of Y. pestis involved in the capsule biogenesis.
作者信息
Karlyshev A V, Galyov E E, Guzayev A P, Abramov V M, Zav'yalov V P
机构信息
Institute of Immunology, State Concern Biopreparation, Lyubuchany, Moscow Region, USSR.
出版信息
FEBS Lett. 1992 Feb 3;297(1-2):77-80. doi: 10.1016/0014-5793(92)80331-a.
The DNA sequence determination of the f1 operon between the genes encoding the F1 subunit (caf1) and chaperone-like protein (caf1M) revealed a large open reading frame that codes for a polypeptide similar to some E. coli proteins involved in the biogenesis of fimbria. The deletion and in trans complementation analyses showed that this gene is not necessary for extracellular transport of the F1 subunit but plays a role in the capsule assembly.
对编码F1亚基（caf1）和伴侣样蛋白（caf1M）的基因之间的f1操纵子进行DNA序列测定，结果显示有一个大的开放阅读框，其编码的多肽类似于一些参与菌毛生物合成的大肠杆菌蛋白。缺失分析和反式互补分析表明，该基因对于F1亚基的细胞外转运不是必需的，但在荚膜组装中起作用。
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