Caf1R基因及其在鼠疫耶尔森菌荚膜形成调控中的作用。
Caf1R gene and its role in the regulation of capsule formation of Y. pestis.
作者信息
Karlyshev A V, Galyov E E, Abramov V M, Zav'yalov V P
机构信息
Institute of Immunology, State Concern Biopreparation, Lyubuchany, Moscow Region, Russia.
出版信息
FEBS Lett. 1992 Jun 22;305(1):37-40. doi: 10.1016/0014-5793(92)80650-6.
PMID:1633857
Abstract
A new transcription unit of the f1 gene cluster was found. The DNA sequencing revealed one long open reading frame. Deletion and frame shift mutation analyses have demonstrated the importance of a corresponding gene product for the F1 antigen biosynthesis. A homology of the deduced amino acid sequence with that of AraC family DNA-binding regulators was shown. A potential regulatory DNA region is discussed.
摘要
发现了f1基因簇的一个新转录单元。DNA测序揭示了一个长开放阅读框。缺失和移码突变分析表明相应基因产物对F1抗原生物合成的重要性。显示了推导的氨基酸序列与AraC家族DNA结合调节因子的氨基酸序列的同源性。讨论了一个潜在的调节性DNA区域。
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