鼠疫耶尔森菌包膜抗原F1的表达由与大肠杆菌伴侣蛋白PapD具有同源性的caf1M基因产物介导。
Expression of the envelope antigen F1 of Yersinia pestis is mediated by the product of caf1M gene having homology with the chaperone protein PapD of Escherichia coli.
作者信息
Galyov E E, Karlishev A V, Chernovskaya T V, Dolgikh D A, Volkovoy K I, Abramov V M, Zav'yalov V P
机构信息
Institute of Immunology, Lyubuchany, Moscow Region, USSR.
出版信息
FEBS Lett. 1991 Jul 29;286(1-2):79-82. doi: 10.1016/0014-5793(91)80945-y.
The effective synthesis of the envelope antigen F1 of Y. pestis in E. coli HB101 is mediated by the expression of the caf1M gene. This gene was sequenced, and the protein encoded was found to have a significant homology with the chaperone protein PapD of uropathogenic E. coli. The data presented allow one to suppose Caf1M and PapD proteins perform similar functions in the biogenesis of the Y. pestis capsule and E. coli P-pili, respectively.
鼠疫耶尔森菌包膜抗原F1在大肠杆菌HB101中的有效合成是由caf1M基因的表达介导的。对该基因进行了测序，发现其编码的蛋白质与致病性大肠杆菌的伴侣蛋白PapD具有显著同源性。所呈现的数据使人们推测Caf1M蛋白和PapD蛋白分别在鼠疫耶尔森菌荚膜和大肠杆菌P菌毛的生物合成中发挥相似的功能。
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