Gregg Dexter, Patil Sachin, Singh Kanwardeep, Marano Michael A, Lee Robin, Petrone Sylvia J, Chamberlain Ronald S
Michigan State University, East Lansing, MI 48824, USA.
Department of Surgery, RWJ Barnabas Health, Livingston, NJ, USA.
Burns. 2018 Feb;44(1):65-69. doi: 10.1016/j.burns.2017.09.018. Epub 2017 Oct 20.
In the United Stated population >70years is likely to double by the year 2050. Elderly population (>70years) are most vulnerable to burns and outcomes following such injuries in this special group is poorly studied. This study aimed to look at outcomes following burns in patients >70years over a period of 17 years.
Data on 6512 patients admitted to a Level I Burn Center between 1995 and 2011 was analyzed. Age, gender, ethnicity, TBSA, burn etiology, hospital and burn intensive care unit (ICU) length of stay (LOS) and status at discharge were abstracted. Three broad categories were created based on presence or absence of smoke inhalation, No smoke inhalation (Group A), smoke inhalation only (Group B) and smoke inhalation with burn injury (Group C). Differences were analyzed using the student's t-test for continuous variables and Chi-Square test for categorical variables.
The study group was comprised of 564 patients, 72.3% in group A, 4.8% in group B and 22.9% in group C formed the study population. The mean age of the patients studied was 80.4±6.7, with female patients being more common (58%). The number of Caucasians (72.9%) was highest in group C compared to other racial groups (p=0.047). Majority of patients in the group B (59.3%) were admitted directly compared to other two groups (group A=24.0%, group B=34.9%, p<0.001). Overall percent total body surface area (% TBSA) and % TBSA third degree burns were higher in group C, whereas % TBSA second degree burns were common in group B (p<0.05). The number ICU admissions, the mean length of ICU stay, mean duration of ventilator support and mean length of hospitalization were all highest in group C patients (p<0.001). The number of discharges to home without home health aide were higher in group A, whereas the number of discharges to nursing home/rehabilitation/extended care facility were higher in group B (p<0.001). The in-hospital mortality (58.1%, p<0.001) and overall burn related mortality (62.8%, p<0.001) were highest in group C. There was no significant difference between the groups for the number of patients converted to hospice care (p=0.21). On multivariate analysis ICU admission (Odds Ratio [OR]=3.7, 95% Confidence Interval [95% CI]=2.1-6.5), ventilator support (OR=7.1, 95% CI=4.1-12.0), and %TBSA >10% (OR=3.1, 95% CI=1.9-5.0) significantly increased mortality. In terms of complications, group C had a significantly higher incidence of pneumonia (18.6%, p<0.001), respiratory failure (17.1%, p=0.001), and sepsis (7.8%, p=0.003).
Patients >70 years constitute small (8.6%) but significant number among burn patients. The overall ICU admissions, number of days on ventilator, ICU stay, in-hospital mortality and overall mortality is higher in this group of population even for low % TBSA burns. Presence of smoke inhalation increases mortality.
到2050年,美国70岁以上的人口数量可能会翻倍。老年人群(>70岁)最容易受到烧伤影响,而针对这一特殊群体烧伤后的预后情况研究较少。本研究旨在观察17年间70岁以上烧伤患者的预后情况。
分析了1995年至2011年期间入住一级烧伤中心的6512例患者的数据。提取了年龄、性别、种族、烧伤总面积(TBSA)、烧伤病因、住院时间以及烧伤重症监护病房(ICU)住院时间和出院状态等信息。根据是否存在吸入性损伤分为三大类:无吸入性损伤(A组)、仅吸入性损伤(B组)和吸入性损伤合并烧伤(C组)。连续变量采用学生t检验分析差异,分类变量采用卡方检验分析差异。
研究组由564例患者组成,A组占72.3%,B组占4.8%,C组占22.9%构成研究人群。研究患者的平均年龄为80.4±6.7岁,女性患者更为常见(58%)。与其他种族群体相比,C组白人数量最多(72.9%)(p=0.047)。与其他两组相比,B组大多数患者(59.3%)直接入院(A组=24.0%,B组=34.9%,p<0.001)。总体烧伤总面积(%TBSA)和三度烧伤的%TBSA在C组更高,而二度烧伤的%TBSA在B组更为常见(p<0.05)。C组患者的ICU入院次数、ICU平均住院时间、呼吸机支持平均时长和平均住院时间均最高(p<0.001)。A组中无需家庭健康护理助理而回家的出院人数较多,而B组中出院至养老院/康复机构/长期护理机构的人数较多(p<0.001)。C组的院内死亡率(58.1%,p<0.001)和总体烧伤相关死亡率(62.8%,p<0.001)最高。各组转为临终关怀的患者数量无显著差异(p=0.21)。多因素分析显示,入住ICU(比值比[OR]=3.7,95%置信区间[95%CI]=2.1-6.5)、呼吸机支持(OR=7.1,95%CI=4.1-12.0)和%TBSA>10%(OR=3.1,95%CI=1.9-5.0)显著增加死亡率。在并发症方面,C组肺炎(18.6%,p<0.001)、呼吸衰竭(17.1%,p=0.001)和败血症(7.8%,p=0.003)的发生率显著更高。
70岁以上的患者在烧伤患者中占比小(8.6%)但数量可观。即使是低%TBSA烧伤,该人群的总体ICU入院次数、呼吸机使用天数、ICU住院时间、院内死亡率和总体死亡率也更高。存在吸入性损伤会增加死亡率。