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广泛胸主动脉瘤的一期修复:采用先主动脉弓技术和双侧前开胸术的经验

Single-stage repair of extensive thoracic aortic aneurysms: experience with the arch-first technique and bilateral anterior thoracotomy.

作者信息

Kouchoukos Nicholas T, Mauney Michael C, Masetti Paolo, Castner Catherine F

机构信息

Division of Cardiovascular and Thoracic Surgery, Missouti Baptist Medical Center, 3009 N. Ballas Road, St. Louis, MO, USA.

出版信息

J Thorac Cardiovasc Surg. 2004 Nov;128(5):669-76. doi: 10.1016/j.jtcvs.2004.06.037.

Abstract

BACKGROUND

Staged procedures for extensive aneurysmal disease of the thoracic aorta are associated with a substantial cumulative mortality (>20%) that includes hospital mortality for the 2 procedures and death (often from aortic rupture) in the interval between the 2 procedures. We have used a single-stage technique for operative repair of most or all of the thoracic aorta.

METHODS

Forty-six patients with extensive disease of the thoracic aorta were managed with a single-stage procedure by using a bilateral anterior thoracotomy and transverse sternotomy, hypothermic circulatory arrest, and reperfusion of the aortic arch vessels first to minimize brain ischemia. Thirty-one patients with chronic, expanding type A aortic dissections had previous operations for acute type A dissection (n = 22), aortic valve repair or replacement (n = 4), coronary artery bypass grafting (n = 4), or no previous operation (n = 1). The remaining 15 patients had degenerative aneurysms (n = 12) or chronic type B dissections with proximal extension (n = 3). The ascending aorta and aortic arch were replaced in all patients combined with resection of various lengths of descending aorta (proximal one third [n = 19], proximal two thirds to three quarters [n = 22], or all [n = 5]). Coronary artery bypass grafting, valve replacement, or both were performed concomitantly in 19 patients.

RESULTS

Hospital mortality was 6.5% (3 patients). Morbidity included reoperation for bleeding (17%), mechanical ventilation for more than 72 hours (42%), temporary tracheostomy (13%), and temporary renal dialysis (9%). No patient sustained a stroke. There have been 5 late deaths (3, 18, 34, 51, and 79 months postoperatively) unrelated to the aortic disease. Four patients have undergone successful reoperation on the aorta (false aneurysm [n = 1], endocarditis [n = 1], and progression of disease [n = 2]). Five-year survival was 75%.

CONCLUSION

The single-stage, arch-first technique is a safe and suitable alternative to the 2-stage procedure for repair of extensive thoracic aortic disease.

摘要

背景

胸主动脉广泛动脉瘤性疾病的分期手术伴有较高的累积死亡率(>20%),包括两次手术的住院死亡率以及两次手术间隔期的死亡(常因主动脉破裂)。我们采用了单阶段技术对大部分或全部胸主动脉进行手术修复。

方法

46例胸主动脉广泛疾病患者采用单阶段手术,通过双侧前外侧开胸和胸骨横断、低温循环停止,并首先对主动脉弓血管进行再灌注以尽量减少脑缺血。31例慢性、扩展性A型主动脉夹层患者曾接受过急性A型夹层手术(n = 22)、主动脉瓣修复或置换(n = 4)、冠状动脉旁路移植术(n = 4),或未曾接受过手术(n = 1)。其余15例患者患有退行性动脉瘤(n = 12)或慢性B型夹层并近端扩展(n = 3)。所有患者均行升主动脉和主动脉弓置换,并切除不同长度的降主动脉(近端三分之一[n = 19]、近端三分之二至四分之三[n = 22]或全部[n = 5])。19例患者同时进行了冠状动脉旁路移植术、瓣膜置换术或两者皆做。

结果

住院死亡率为6.5%(3例患者)。并发症包括因出血再次手术(17%)、机械通气超过72小时(42%)、临时气管切开(13%)和临时肾透析(9%)。无患者发生卒中。有5例晚期死亡(术后3、18、34、51和79个月)与主动脉疾病无关。4例患者成功接受了主动脉再次手术(假性动脉瘤[n = 1]、心内膜炎[n = 1]和疾病进展[n = 2])。五年生存率为75%。

结论

单阶段、先主动脉弓技术是修复广泛胸主动脉疾病的两阶段手术的一种安全且合适的替代方法。

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