大鼠个体发育早期日粮中蛋白质缺乏与成年后消化和非消化器官酶系统功能之间的关系。
Relationship between protein deficiency in the ration of rats during early ontogeny and function of enzyme systems of digestive and non-digestive organs in adult life.
作者信息
Timofeeva N M, Nikitina A A, Egorova V V, Gordova L A
机构信息
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
出版信息
Bull Exp Biol Med. 2004 Jul;138(1):8-11. doi: 10.1023/b:bebm.0000046924.75052.f3.
Low protein content in the ration of rat pups during transfer from mixed to definitive nutrition (days 21-30 of life) has a negative impact on digestive function of the small intestine and trophic and barrier functions of the large intestine, liver, and kidneys and increases (sucrase, glycyl-L-leucin dipeptidase) or decreases (alkaline phosphatase, aminopeptidase M, glycyl-L-leucine dipeptidase) enzyme activities in these organs in 6-month-old rats. Protein deficiency during the early ontogeny modulates functioning of the enzyme systems in digestive and non-digestive organs in adult life, which can lead to the development of not only gastrointestinal, but other visceral diseases.
在从混合营养过渡到确定营养期间（出生后第21 - 30天），给幼鼠喂食低蛋白日粮会对小肠的消化功能以及大肠、肝脏和肾脏的营养和屏障功能产生负面影响，并会增加（蔗糖酶、甘氨酰 - L - 亮氨酸二肽酶）或降低（碱性磷酸酶、氨肽酶M、甘氨酰 - L - 亮氨酸二肽酶）6月龄大鼠这些器官中的酶活性。个体发育早期的蛋白质缺乏会调节成年后消化和非消化器官中酶系统的功能，这不仅会导致胃肠道疾病，还会引发其他内脏疾病。
Zotero 插件