Timofeeva N M, Egorova V V, Nikitina A A, Dmitrieva Iu V
Zh Evol Biokhim Fiziol. 2009 May-Jun;45(3):290-7.
Activities of digestive enzymes (maltase, alkaline phosphatase, amino peptidase M, and glycyl-L-leucine dipeptidase) in small and large intestine, liver, and kidney were studied in rats of different ages kept in normal (8) and low (3) amounts of pups per litter. The low-protein diet for 10 days at once after weaning was found to change the mass of the organs and their digestive enzyme activities in all studied rat groups. The revealed changes were more prominent in rats kept under conditions of breast-overfeeding. In adult animals of this group, distribution of the alkaline phosphatase activity along the small intestine differed from that in control rats. The obtained results seem to confirm the fact that any disturbance of the nutrition quality in early ontogenesis leads to disturbance of the "metabolic programming of enzyme systems" of digestive and non-digestive organs.
对不同年龄的大鼠进行了研究，这些大鼠每窝幼崽数量正常（8只）或较少（3只），并分别饲养在正常和低蛋白环境中。研究了大鼠小肠、大肠、肝脏和肾脏中消化酶（麦芽糖酶、碱性磷酸酶、氨基肽酶M和甘氨酰-L-亮氨酸二肽酶）的活性。结果发现，断奶后立即给予10天的低蛋白饮食会改变所有研究大鼠组的器官质量及其消化酶活性。在过度哺乳条件下饲养的大鼠中，所揭示的变化更为明显。在该组成年动物中，碱性磷酸酶活性沿小肠的分布与对照大鼠不同。所得结果似乎证实了这样一个事实，即早期个体发育中营养质量的任何干扰都会导致消化和非消化器官“酶系统的代谢编程”紊乱。
