Maksimov V F, Korostyshevskaya I M, Markel' A L, Shmerling M D, Yakobson G S
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Bull Exp Biol Med. 2004 Jul;138(1):1-4. doi: 10.1023/b:bebm.0000046922.44833.13.
Electron microscopy and stereomorphometric analysis of hypertrophic cardiomyocytes in the right atrium of NISAG rats revealed signs of activation of biosynthetic processes: increased relative volume of euchromatin (compared to Wistar rats), high density of nuclear pores, presence of large numerous Golgi complexes, and well-developed endoplasmic reticulum. The numerical density of secretory granules in the cytoplasm of cardiomyocytes in NISAG rats significantly surpassed that in Wistar rats. However, these granules in NISAG rats were smaller than in Wistar rats. The presence of numerous secretory granules and increased ratio of forming and dissolving structures suggest that this pool is characterized by high turnover rate, i.e., intensive synthesis and rapid elimination (consumption) of natriuretic peptide. Hypertrophy and hyperactivity of endocrine function in atrial cardiomyocytes of NISAG rats can be considered as a compensatory reaction to hypertension.
对NISAG大鼠右心房肥厚心肌细胞进行电子显微镜检查和立体形态计量分析，结果显示生物合成过程激活的迹象：常染色质相对体积增加（与Wistar大鼠相比）、核孔密度高、存在大量大型高尔基体复合物以及发达的内质网。NISAG大鼠心肌细胞胞质中分泌颗粒的数量密度显著超过Wistar大鼠。然而，NISAG大鼠的这些颗粒比Wistar大鼠的小。大量分泌颗粒的存在以及形成和溶解结构比例的增加表明，这个池的特点是周转率高，即利钠肽的合成强烈且消除（消耗）迅速。NISAG大鼠心房心肌细胞的肥大和内分泌功能亢进可被视为对高血压的一种代偿反应。
