Korostyshevskaya I M, Maksimov V F, Markel A L, Shmerling M D, Buzueva I I, Filyushina Ye Ye, Yakobson G S
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2012 Sep;153(5):771-4. doi: 10.1007/s10517-012-1823-4.
Ultrastructure of the right atrial cardiomyocytes of suckling ISIAH rats was studied to clarify the role of cardiac natriuretic peptides in hypertension development during the period when blood pressure is not yet elevated. Cardiomyocytes diameter was significantly greater, Golgi complex was more developed, and granules in the sarcoplasm were more abundant in ISIAH rats as soon as on postnatal day 12 in comparison with age-matched normotensive animals. The smaller diameter of granules and their qualitative composition (ratio of forming, mature, and dissolving forms) attest to active synthesis and release of secretory product. In 21-day-old ISIAH rats, granule size and qualitative composition reflected increased accumulation of hormones in the cells. Thus, morphological features of increased production of natriuretic peptides in the right atrial myocytes were revealed in rats during the first postnatal month before manifestation of hereditary hypertension.
研究了乳鼠期自发性高血压易感大鼠（ISIAH）右心房心肌细胞的超微结构，以阐明在血压尚未升高期间心钠素在高血压发展中的作用。与年龄匹配的正常血压动物相比，ISIAH大鼠在出生后第12天，心肌细胞直径明显更大，高尔基体更发达，肌浆中的颗粒更丰富。颗粒较小的直径及其定性组成（形成、成熟和溶解形式的比例）证明了分泌产物的活跃合成和释放。在21日龄的ISIAH大鼠中，颗粒大小和定性组成反映了细胞内激素积累的增加。因此，在遗传性高血压表现出来之前的出生后第一个月，在大鼠右心房肌细胞中发现了心钠素产生增加的形态学特征。
