Central Research Laboratory, Institute of Fundamental Medicine, Volga Region Research Medical University, Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia.
Bull Exp Biol Med. 2020 Jun;169(2):197-200. doi: 10.1007/s10517-020-04849-y. Epub 2020 Jul 10.
The intensity of accumulation and excretion of atrial natriuretic peptide in myocytes of the right atrium in rat models of renovascular hypertension and salt loading was studied by immunocytochemical analysis and transmission electron microscopy. The data suggest that high BP is not the decisive factor affecting secretion of atrial natriuretic peptide in atrial cardiomyocytes. The regulatory mechanisms of the accumulation and release of the peptide from myocyte granules can vary and depend on the pathogenesis of hypertension.
免疫细胞化学分析和透射电镜研究了血管紧张素Ⅱ型受体拮抗剂氯沙坦对盐负荷大鼠心肌细胞钠尿肽分泌的影响。结果表明，氯沙坦不仅通过降低血压，而且通过非降压机制，减少心肌细胞钠尿肽的分泌。
