氮丙啶硫化物和二硫化物作为二乙基锌对醛进行对映选择性加成反应的催化剂。
Aziridine sulfides and disulfides as catalysts for the enantioselective addition of diethylzinc to aldehydes.
作者信息
Braga Antonio L, Milani Priscila, Paixão Marcio W, Zeni Gilson, Rodrigues Oscar E D, Alves Elenilson F
机构信息
Departamento de Química, Universidade Federal de Santa Maria, 97105-900-Santa Maria-RS, Brazil.
出版信息
Chem Commun (Camb). 2004 Nov 7(21):2488-9. doi: 10.1039/b408537j. Epub 2004 Sep 14.
DOI:10.1039/b408537j
PMID:15514829
Abstract
Chiral aziridine sulfides and disulfides were synthesized from readily available and inexpensive R-cysteine by a Mitsunobu reaction; their application in the addition of diethylzinc to aldehydes provides secondary alcohols with up to 99% ee and S-configuration.
摘要
手性氮丙啶硫化物和二硫化物由易于获得且价格低廉的R-半胱氨酸通过光延反应合成；它们在二乙基锌与醛的加成反应中的应用可提供对映体过量高达99%且具有S-构型的仲醇。
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