二烷基锌试剂对开链硝基烯烃的高度对映选择性共轭加成：一种合成β2-氨基酸、醛和醇的催化途径。
Highly enantioselective conjugate addition of dialkylzinc reagents to acyclic nitroalkenes: a catalytic route to beta2-amino acids, aldehydes, and alcohols.
作者信息
Duursma Ate, Minnaard Adriaan J, Feringa Ben L
机构信息
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, The Netherlands.
出版信息
J Am Chem Soc. 2003 Apr 2;125(13):3700-1. doi: 10.1021/ja029817d.
PMID:12656591
Abstract
Using chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition to acyclic nitroalkenes for the first time, we obtained enantioselectivities up to 98%. The use of acyclic substrates with different dialkylzinc reagents provides a catalytic enantioselective route to (functionalized) beta2-amino aldehydes, acids, and alcohols.
摘要
首次在手性亚磷酰胺配体（S，R，R）-L1对非环状硝基烯烃的共轭加成反应中，我们获得了高达98%的对映选择性。使用带有不同二烷基锌试剂的非环状底物，为制备（官能化的）β2-氨基醛、酸和醇提供了一条催化对映选择性途径。
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