Teksam M, McKinney A, Short J, Casey S O, Truwit C L
University of Minnesota Medical School and Hennepin County Medical Center Departments of Radiology, Minneapolis, Minn, USA.
Acta Radiol. 2004 Aug;45(5):577-9. doi: 10.1080/02841850410005660.
We present the computed tomography (CT) and magnetic resonance imaging (MRI) findings of brain metastases in an unusual case of a premature, 33-week gestational age neonate who was emergently delivered from a mother suspected of having lung cancer according to imaging performed during the third trimester of pregnancy. Owing to the presence of placental metastases noted after delivery, the fetus had initial screening with brain MRI and chest/abdomen CT as well as serial screening imaging studies during the first 5 months of life, all of which were apparently normal. However, serial examinations eventually revealed a cerebellar lesion that significantly improved after chemotherapy but recurred and enlarged within a few months. This lesion was later confirmed to be metastasis by subsequent biopsy and resection. More metastatic lesions were identified in the frontal and temporal lobes on follow-up MRI. In the setting of aggressive maternal malignancy (without known fetal primary malignancy) an intracranial mass can, on the exceedingly rare occasion, result from maternal high-grade malignancy and the neuroradiologist should be alerted to this phenomenon.
我们报告了一名孕33周早产新生儿脑转移瘤的计算机断层扫描（CT）和磁共振成像（MRI）结果。该新生儿母亲在妊娠晚期的影像学检查疑似患有肺癌，随后紧急分娩。由于产后发现胎盘转移，该胎儿在出生后的前5个月接受了脑部MRI和胸部/腹部CT的初步筛查以及系列筛查影像学检查，结果均显示正常。然而，系列检查最终发现了一个小脑病变，化疗后明显改善，但数月后复发并增大。该病变后来经后续活检和切除证实为转移瘤。随访MRI在额叶和颞叶发现了更多转移瘤。在母亲患有侵袭性恶性肿瘤（未知胎儿原发性恶性肿瘤）的情况下，极罕见地，颅内肿块可能由母亲的高级别恶性肿瘤引起，神经放射科医生应警惕这种现象。
