[转化生长因子-β1（TGF-β1）在人喉癌和下咽癌中的表达及其作用]
[Expression of transforming growth factor-betal (TGF-beta1) and its role in human laryngeal and hypopharyngeal carcinoma].
作者信息
Chen Xuemei, Zhang Daliang, Zhao Jiandong, Wang Rui, Feng Jinbo, Xu Xiaoqun, Wei Haiming
机构信息
Department of Otolaryngology, the Second Affiliated Hospital of Shandong University, Jinan 250033.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Sep;16(9):457-8.
OBJECTIVE
To detect the mRNA expression of transforming growth factor-betal (TGF-beta1) in laryngeal and hypopharyngeal carcinoma, and to explore the pathogenesis of the two types neoplasms.
METHOD
We examined the expression of TGF-beta1 mRNA in the tissue of human laryngeal and hypopharyngeal carcinoma from patients. The TGF-beta1 mRNA expression was determined by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR).
RESULT
The TGF-beta1 mRNA expression was significantly stronger in 17 cases of 20 laryngeal and hypopharyngeal carcinoma.
CONCLUSION
The result suggested that the expression level of TGF-beta1 in laryngeal and hypopharyngeal carcinoma may inhibit the human immunity and enhance the growth and metastasis of the laryngeal and hypopharyngeal carcinoma.
目的
检测转化生长因子-β1（TGF-β1）在喉癌和下咽癌中的mRNA表达，探讨这两种肿瘤的发病机制。
方法
检测患者人喉癌和下咽癌组织中TGF-β1 mRNA的表达。采用半定量逆转录聚合酶链反应（RT-PCR）测定TGF-β1 mRNA的表达。
结果
20例喉癌和下咽癌中17例TGF-β1 mRNA表达明显增强。
结论
结果提示，喉癌和下咽癌中TGF-β1的表达水平可能抑制人体免疫，促进喉癌和下咽癌的生长和转移。
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