Flatau E, Bshara H, Shimoni Z, Shneyour A
Dept. of Medicine B, Hospital of the Emek, Afula.
Harefuah. 1992 Jan 1;122(1):1-4.
Sera from 183 healthy, elderly subjects and 92 young, control subjects were tested by the Elisa method for antibodies against double-stranded (ds) and single-stranded (ss) DNA, and sera from the elderly were tested for antinuclear antibodies as well. Significantly higher levels of anti-ss-DNA were found in the elderly, but levels of anti-ds-DNA did not differ significantly; no sera positive for anti-ds-DNA were found. levels of antibodies to DNA were similar in men and women. In those 85 and over, mean levels of anti-ds-DNA were lower than in those 65-84 (63 vs. 44, p less than 0.05). 13 of those over 65 (7.1%) tested positive for antinuclear factor, 2 of whom had positive titers of anti-ss-DNA. The results of this study support the hypothesis that elevated levels of anti-ss-DNA are age-related and not disease-related.
采用酶联免疫吸附测定（ELISA）法检测了183名健康老年受试者和92名年轻对照受试者血清中的抗双链（ds）和单链（ss）DNA抗体，同时也检测了老年受试者血清中的抗核抗体。结果发现，老年人血清中抗ss-DNA水平显著升高，但抗ds-DNA水平无显著差异，且未发现抗ds-DNA阳性血清。男性和女性的DNA抗体水平相似。在85岁及以上人群中，抗ds-DNA的平均水平低于65-84岁人群（分别为63和44，p<0.05）。65岁以上人群中有13人（7.1%）抗核因子检测呈阳性，其中2人抗ss-DNA滴度呈阳性。本研究结果支持抗ss-DNA水平升高与年龄相关而非与疾病相关这一假说。
