Dangoisse C
Service de Dermatologie, Hôpital Universitaire des Enfants Reine Fabiola, ULB, Bruxelles.
Rev Med Brux. 2004 Sep;25(4):A365-70.
Skin aging is the result of the addition of intrinsic aging (chronological aging) and extrinsic aging induced by environmental factors among whose ultraviolet radiation plays a predominant role (actinic aging). The physiopathological mechanisms of skin aging are well better known. UV radiations act either directly on DNA either through the formation of free radicals. The skin aging is characterized by the decline of numerous skin functions. Its clinical presentation is accentuated in UV exposed-skin. To struggle against skin aging is first of all to prevent it by means of an efficient photoprotection, an adequate general life style and preventive treatments as alpha-hydroxyacids, retinoids and antioxidants.
皮肤老化是内在老化(自然老化)与环境因素导致的外在老化相加的结果,其中紫外线辐射起主要作用(光化性老化)。皮肤老化的生理病理机制已广为人知。紫外线辐射可通过自由基的形成直接作用于DNA。皮肤老化的特征是多种皮肤功能下降。其临床表现在暴露于紫外线的皮肤中更为明显。对抗皮肤老化首先要通过有效的光防护、适当的总体生活方式以及如α-羟基酸、维甲酸和抗氧化剂等预防性治疗来预防。