Mehta Rahul C, Fitzpatrick Richard E
Research and Development, SkinMedica, Inc., Carlsbad, California, USA.
Dermatol Ther. 2007 Sep-Oct;20(5):350-9. doi: 10.1111/j.1529-8019.2007.00149.x.
Growth factors play an important role in reversing the effects of skin aging mediated by chronological and environmental factors. Excessive oxidation of intra- and extracellular components result in breakdown of collagen and elastin network in the dermis and produce the effect of facial aging. Topical application of human growth factors in multiple clinical studies has been shown to reduce the signs and symptoms of skin aging, including statically significant reduction in fine lines and wrinkles and increase in dermal collagen synthesis. More double-blind and controlled studies are needed to confirm the preliminary clinical effects of growth factor products, and more controls on product quality and stability need to be established.
生长因子在逆转由自然衰老和环境因素介导的皮肤衰老效应方面发挥着重要作用。细胞内和细胞外成分的过度氧化会导致真皮中胶原蛋白和弹性蛋白网络的分解，并产生面部衰老的效果。在多项临床研究中，局部应用人类生长因子已被证明可减少皮肤衰老的体征和症状，包括细纹和皱纹在统计学上显著减少以及真皮胶原蛋白合成增加。需要更多的双盲对照研究来证实生长因子产品的初步临床效果，并且需要对产品质量和稳定性建立更多的控制措施。
