Department of Pharmacy Services, Detroit Receiving Hospital, Detroit, MI, USA.
Ther Clin Risk Manag. 2009 Jun;5(3):485-9. doi: 10.2147/tcrm.s3777. Epub 2009 Jul 12.
Bacterial vaginosis (BV) is a complex vaginal infection most commonly associated with women of child-bearing age. Risk factors for BV are numerous. There are currently multiple clinical and laboratory tests for diagnosis of BV, including the most commonly used diagnostic methods: Amsel's criteria or Nugent's Gram stain scale. The mainstay of BV therapy is metronidazole, but tinidazole as well as a few other agents have also been used successfully. Tinidazole is the second nitroimidazole antiprotozoal agent and a structural derivative of metronidazole. With a favorable pharmacokinetic profile and reduced side effects, tinidazole is an alternative agent for BV treatment. There are minimal head-to-head comparative data to establish tinidazole's superiority to metronidazole or other therapeutic agents. Available data suggest tinidazole has a role in special populations particularly for refractory or relapsing BV.
细菌性阴道病（BV）是一种常见于育龄妇女的复杂阴道感染。BV 的危险因素很多。目前有多种临床和实验室检测方法用于诊断 BV，包括最常用的诊断方法：Amsel 标准或 Nugent 革兰氏染色量表。BV 的主要治疗方法是甲硝唑，但替硝唑以及其他一些药物也已成功应用。替硝唑是第二代硝基咪唑抗寄生虫药物，也是甲硝唑的结构衍生物。替硝唑具有良好的药代动力学特性和较少的副作用，是治疗 BV 的替代药物。目前几乎没有头对头的比较数据来确定替硝唑优于甲硝唑或其他治疗药物。现有数据表明，替硝唑在特殊人群中，特别是在难治性或复发性 BV 中具有一定作用。
