Piipari R, Jaakkola J J K, Jaakkola N, Jaakkola M S
Finnish Institute of Occupational, University of Helsinki, Helsinki, Finland.
Eur Respir J. 2004 Nov;24(5):734-9. doi: 10.1183/09031936.04.00116903.
Studies on the effect of smoking on adulthood asthma have provided contradictory results. The current authors conducted a population-based incident case-control study to assess the effects of current and past smoking on the development of asthma in adults. During a 2.5 yr study period, all new asthma cases clinically diagnosed (n=521) and randomly selected controls (n=932) from a geographically defined district in southern Finland were recruited. The risk of developing asthma was significantly higher among current smokers with an adjusted odds ratio (OR) of 1.33 (95% confidence interval 1.00-1.77) and among ex-smokers with an adjusted OR 1.49 (1.12-1.97) compared with never-smokers. Among current smokers, the risk increased up to 14 cigarettes x day(-1), and a similar trend was observed in relation to cumulative smoking. In conclusion, the current results support the hypothesis that smoking causes asthma in adulthood.
关于吸烟对成年期哮喘影响的研究结果相互矛盾。本文作者开展了一项基于人群的病例对照研究，以评估当前吸烟和既往吸烟对成人哮喘发病的影响。在2.5年的研究期间，从芬兰南部一个地理区域内招募了所有临床诊断的新发哮喘病例（n = 521）以及随机选择的对照（n = 932）。与从不吸烟者相比，当前吸烟者患哮喘的风险显著更高，调整后的优势比（OR）为1.33（95%置信区间1.00 - 1.77），既往吸烟者的调整后OR为1.49（1.12 - 1.97）。在当前吸烟者中，风险增加至每天14支香烟（-1），并且在累积吸烟方面也观察到类似趋势。总之，当前结果支持吸烟导致成年期哮喘这一假说。
