Center for Environmental and Respiratory Health Research, Research Unit of Population Health, University of Oulu, FI-90014 Oulu, Finland.
Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.
Int J Environ Res Public Health. 2023 Feb 9;20(4):3072. doi: 10.3390/ijerph20043072.
Only a few previous studies have investigated the subtypes of adult-onset asthma. No previous study has assessed whether these subtypes are different between men and women, or whether these subtypes have different risk factors.
We applied latent class analyses to the Finnish Environment and Asthma Study population, including 520 new cases of adult-onset asthma. We formed subtypes separately between women and men and analyzed the following determinants as potential predictors for these subtypes: age, body mass index, smoking, and parental asthma.
Among women, the subtypes identified were: 1. , 2. , 3. , 4. , and 5. . Among men, the subtypes were: 1. , 2. , 3. , and 4. . Three of the subtypes were similar among women and men: , and . In addition, women had two distinct subtypes: , and . These subtypes had different risk factor profiles, e.g., heredity was important for and (RR for Both parents having asthma in Eosinophilic 3.55 (1.09 to 11.62)). Furthermore, smoking increased the risk of among women (RR for former smoking 2.21 (1.19 to 4.11)) and among men but had little influence on or Conclusion: This is an original investigation of the subtypes of adult-onset asthma identified at the time of diagnosis. These subtypes differ between women and men, and these subtypes have different risk factor profiles. These findings have both clinical and public health importance for the etiology, prognosis, and treatment of adult-onset asthma.
仅有少数既往研究调查了成人起病哮喘的亚型。既往研究尚未评估这些亚型在男性和女性之间是否不同，或这些亚型是否具有不同的危险因素。
我们对芬兰环境与哮喘研究人群（包括 520 例新发生的成人起病哮喘病例）应用潜在类别分析。我们分别在女性和男性中形成亚型，并分析以下决定因素作为这些亚型的潜在预测因素：年龄、体重指数、吸烟和父母哮喘。
在女性中，确定的亚型为：1. ；2. ；3. ；4. ；5. 。在男性中，亚型为：1. ；2. ；3. ；4. 。有 3 种亚型在女性和男性中相似：1. ；2. ；3. 。此外，女性有两种独特的亚型：1. ；2. 。这些亚型具有不同的危险因素特征，例如遗传对嗜酸性粒细胞 3. （双亲均患哮喘的 RR 为 3.55（1.09 至 11.62））和 （RR 为 Both parents having asthma in Eosinophilic 3.55（1.09 to 11.62））很重要。此外，吸烟增加了女性患 （RR for former smoking 2.21（1.19 至 4.11））和 （RR for former smoking 2.21（1.19 至 4.11））的风险，但对 或 影响不大。结论：这是对诊断时成人起病哮喘亚型的原始研究。这些亚型在女性和男性之间不同，这些亚型具有不同的危险因素特征。这些发现对成人起病哮喘的病因学、预后和治疗具有临床和公共卫生意义。
