来自毛叶大丁草（Gerbera piloselloides (L.) CASS.）的两种新型二香豆素对薄荷烷类化合物

Two novel dicoumaro-p-menthanes from Gerbera piloselloides (L.) CASS.

作者信息

Xiao Ying, Ding Yi, Li Jian-Bei, Nohara Toshihiro

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100-050, China.

出版信息

Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1362-4. doi: 10.1248/cpb.52.1362.

DOI:10.1248/cpb.52.1362

PMID:15516764

Abstract

Two new type dicoumarins (dicoumaro-p-menthanes), named dibothrioclinins I (1) and II (2) were isolated from the roots and rhizomes of Gerbera piloselloides (L.) CASS., collected in Yunnan Province, China. Their structures were elucidated on the basis of MS, 1D ((1)H-NMR, (13)C-NMR, DEPT and NOE) and 2D ((1)H-(1)H COSY, HMQC, HMBC) NMR spectral analyses. The relative structures of the two compounds were established by NOE difference spectroscopy and further confirmed by single-crystal X-ray diffraction studies.

摘要

从中国云南省采集的堆心菊（Gerbera piloselloides (L.) CASS.）的根和根茎中分离出两种新型香豆素（二香豆素对薄荷烷），命名为双孢克林宁 I（1）和 II（2）。基于质谱、一维（¹H-NMR、¹³C-NMR、DEPT 和 NOE）和二维（¹H-¹H COSY、HMQC、HMBC）核磁共振光谱分析阐明了它们的结构。通过 NOE 差光谱确定了这两种化合物的相对结构，并通过单晶 X 射线衍射研究进一步证实。