Aho Allan J, Tirri Teemu, Kukkonen Juha, Strandberg Niko, Rich Jaana, Seppälä Jukka, Yli-Urpo Antti
Department of Surgery, Turku University Central Hospital, Finland and Biomaterials Research, Institute of Dentistry, University of Turku, Finland.
J Mater Sci Mater Med. 2004 Oct;15(10):1165-73. doi: 10.1023/B:JMSM.0000046401.50406.9b.
Injectable composites (Glepron) of particulate bioactive glass S53P4 (BAG) and Poly(epsilon-caprolactone-co-D,L-lactide) as thermoplastic carrier matrix were investigated as bone fillers in cancellous and cartilagineous subchondral bone defects in rabbits. Composites were injected as viscous liquid or mouldable paste. The glass granules of the composites resulted in good osteoconductivity and bone bonding that occurred initially at the interface between the glass and the host bone. The bone bioactivity index (BBI) indicating bone contacts between BAG and bone, as well as the bone coverage index (BCI) indicating bone ongrowth, correlated with the amount of glass in the composites. The indices were highest with 70 wt % of BAG, granule size 90-315 microm and did not improve by the addition of sucrose as in situ porosity creating agent in the composite or by using smaller (<45 microm) glass granules. The percentage of new bone ingrowth into the composite with 70 wt % of BAG was 6-8% at 23 weeks. At the articular surface cartilage regeneration with chondroblasts and mature chondrocytes was often evident. The composites were osteoconductive and easy to handle with short setting time. They were biocompatible with low foreign body cellular reaction. Results indicate a suitable working concept as a filler bone substitute for subchondral cancellous bone defects.
研究了颗粒状生物活性玻璃S53P4（BAG）与聚（ε-己内酯-co-D，L-丙交酯）作为热塑性载体基质的可注射复合材料（Glepron），将其作为兔松质骨和软骨下骨缺损的骨填充材料。复合材料以粘性液体或可塑糊剂形式注射。复合材料中的玻璃颗粒具有良好的骨传导性和骨结合能力，最初在玻璃与宿主骨的界面处发生。表示BAG与骨之间骨接触的骨生物活性指数（BBI）以及表示骨生长的骨覆盖指数（BCI）与复合材料中玻璃的含量相关。当BAG含量为70 wt%、颗粒尺寸为90 - 315微米时，这些指数最高，并且在复合材料中添加蔗糖作为原位孔隙形成剂或使用更小（<45微米）的玻璃颗粒时，指数并未提高。含70 wt%BAG的复合材料在23周时新骨长入的百分比为6 - 8%。在关节表面，软骨细胞和成软骨细胞的软骨再生常常很明显。该复合材料具有骨传导性，易于操作，凝固时间短。它们具有生物相容性，异物细胞反应低。结果表明，作为软骨下松质骨缺损的填充性骨替代物，这是一种合适的工作理念。
