Mills Kingston H G
Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland.
Nat Rev Immunol. 2004 Nov;4(11):841-55. doi: 10.1038/nri1485.
Homeostasis in the immune system depends on a balance between the responses that control infection and tumour growth and the reciprocal responses that prevent inflammation and autoimmune diseases. It is now recognized that regulatory T cells have a crucial role in suppressing immune responses to self-antigens and in preventing autoimmune diseases. Evidence is also emerging that regulatory T cells control immune responses to bacteria, viruses, parasites and fungi. This article explores the possibility that regulatory T cells can be both beneficial to the host, through limiting the immunopathology associated with anti-pathogen immune responses, and beneficial to the pathogen, through subversion of the protective immune responses of the host.
免疫系统的稳态取决于控制感染和肿瘤生长的反应与防止炎症和自身免疫性疾病的相互反应之间的平衡。现在人们认识到，调节性T细胞在抑制对自身抗原的免疫反应和预防自身免疫性疾病方面起着至关重要的作用。也有证据表明，调节性T细胞控制对细菌、病毒、寄生虫和真菌的免疫反应。本文探讨了调节性T细胞可能既通过限制与抗病原体免疫反应相关的免疫病理对宿主有益，又通过颠覆宿主的保护性免疫反应对病原体有益的可能性。
