Nadal Angel, Alonso-Magdalena Paloma, Ripoll Cristina, Fuentes Esther
Institute of Bioengineering, School of Medicine, Miguel Hernández University, Sant Joan Campus, Carretera Alicante-Valencia Km 87, 03550 Alicante, Spain.
Pflugers Arch. 2005 Jan;449(4):335-43. doi: 10.1007/s00424-004-1343-9. Epub 2004 Oct 29.
The gonadal hormone 17beta-estradiol is involved in numerous cellular processes. In many cases, 17beta-estradiol actions are imitated by synthetic and natural chemicals in the environment. Their actions differ depending on the target tissue, the receptors involved and the molecular pathways activated. The plethora of estrogenic actions is triggered by different receptors and other specific structures that activate different signalling pathways. This amount of information may lead to a maze of effects triggered by endogenous and environmental estrogens that we intend to clarify in this review. Understanding the variety of estrogen receptors, their different locations and the signalling pathways activated by estrogenic ligands is fundamental for understanding the diversity of actions that estrogens have in different tissues and cells.
性腺激素17β-雌二醇参与众多细胞过程。在许多情况下，环境中的合成化学物质和天然化学物质会模仿17β-雌二醇的作用。它们的作用因靶组织、所涉及的受体以及激活的分子途径而异。大量的雌激素作用是由不同的受体和其他激活不同信号通路的特定结构触发的。这些信息可能会导致内源性和环境雌激素引发的一系列效应变得错综复杂，而我们打算在本综述中加以阐明。了解雌激素受体的多样性、它们的不同位置以及雌激素配体激活的信号通路，对于理解雌激素在不同组织和细胞中的作用多样性至关重要。
