Nasr Suhayl
Nasr Psychiatric Services, PC, Michigan City, Indiana 46360, USA.
Ann Clin Psychiatry. 2004 Jul-Sep;16(3):133-8. doi: 10.1080/10401230490486954.
The wake-promoting agent modafinil (PROVIGIL) may prove useful as an adjunctive treatment in patients with suboptimal responses to antidepressant regimens. This retrospective chart review describes the use of modafinil as an adjunct to antidepressant therapy in 78 outpatients in a general psychiatric practice and discusses in detail treatment outcomes for 3 patients. Statistically significant improvements in mean Carroll Depression Rating Scale scores (p < 0.01), Visual Analog Scale scores for overall feeling (p < 0.003), and Clinical Global Impression of Severity ratings (p < 0.001) were demonstrated following treatment with modafinil. Treatment with modafinil rapidly improved wakefulness, fatigue, and everyday functioning in individual cases. Modafinil was well tolerated in combination with antidepressants and other medications. These findings suggest that adjunctive modafinil may improve treatment outcomes when used with antidepressant therapy in depressed patients, particularly in those with problematic sleepiness or fatigue.
促醒药物莫达非尼（安非他明）可能被证明是对抗抑郁治疗方案反应欠佳患者的一种辅助治疗手段。这项回顾性病历审查描述了在一家普通精神病诊所中78名门诊患者使用莫达非尼作为抗抑郁治疗辅助药物的情况，并详细讨论了3名患者的治疗结果。使用莫达非尼治疗后，卡罗尔抑郁评定量表平均得分（p < 0.01）、整体感觉视觉模拟量表得分（p < 0.003）和临床总体印象严重程度评分（p < 0.001）有统计学意义的显著改善。在个别病例中，使用莫达非尼能迅速改善觉醒、疲劳和日常功能。莫达非尼与抗抑郁药及其他药物联合使用时耐受性良好。这些发现表明，辅助使用莫达非尼与抗抑郁治疗联合用于抑郁症患者时，可能会改善治疗结果，尤其是对那些有睡眠问题或疲劳问题的患者。
