Gupta Sanjay, Masand Prakash
Department of Psychiatry, University of Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
Ann Clin Psychiatry. 2004 Jul-Sep;16(3):155-66. doi: 10.1080/10401230490487007.
The discovery of antipsychotic medications has revolutionized the treatment of schizophrenia and other psychotic disorders. However, side effects such as extrapyramidal symptoms (EPS) and tardive dyskinesia (TD), electrocardiogram (ECG) changes, weight gain, and metabolic disturbances indicate the continued need to develop new agents. The introduction of atypical drugs such as clozapine, risperidone, olanzapine, quetiapine, and ziprasidone has widened our choices. This article provides an overview of the pharmacology, efficacy, and techniques for the clinical use of aripiprazole, a novel agent with a unique pharmacological profile.
抗精神病药物的发现彻底改变了精神分裂症和其他精神障碍的治疗方式。然而，诸如锥体外系症状（EPS）、迟发性运动障碍（TD）、心电图（ECG）改变、体重增加和代谢紊乱等副作用表明，仍有持续开发新药物的需求。氯氮平、利培酮、奥氮平、喹硫平和齐拉西酮等非典型药物的引入拓宽了我们的选择范围。本文概述了阿立哌唑的药理学、疗效及临床应用技术，阿立哌唑是一种具有独特药理学特性的新型药物。
