Cumurcu Tongabay, Cumurcu Birgul Elbozan, Yesil Bahar, Gunduz Abuzer
Department of Ophthalmology, Inonu University Faculty of Medicine, Malatya, Turkey.
Department of Psychiatry, Inonu University Faculty of Medicine, Malatya, Turkey.
North Clin Istanb. 2019 Jul 12;7(5):516-518. doi: 10.14744/nci.2019.65625. eCollection 2020.
This study aims to present a case of transient myopia due to aripiprazole used in the treatment of depression. A 21-year-old female who was being treated for depression with 15 mg/day Aripiprazole during two months. She normally used -3.75 D glasses. She was admitted to our outpatient clinic with sudden onset blurring of vision in both eyes despite using glasses for about three days. Using of aripiprazole was observed in the patient's history. She was found to have myopia of -6.0 diopters in both eyes with measurement of otorefractometer; her visual acuity was 6/10 in both eyes with her glasses. The other eye examination findings of the patient were normal. The drug was discontinued, and the patient was followed. One mount later on examination, the patient's visual acuity increased to 10/10 in both eyes. Following the first day of the Alx values measured were 0.3 mm longer than one month after the measurement; the minimal difference between the other anterior segment findings were recorded. Although the specific mechanisms that cause acute myopia has not been fully revealed, it can be ciliary spasm, ciliary bodies effusion, peripheral uveal effusion and effects of ocular serotonergic intraneural fibers. We believe that it would be important for clinicians. They should keep in mind these conditions when prescribing aripiprazole and need to inform patients about the side effects related to the eye.
本研究旨在呈现一例因使用阿立哌唑治疗抑郁症而导致短暂性近视的病例。一名21岁女性，在两个月内每天使用15毫克阿立哌唑治疗抑郁症。她平时佩戴-3.75 D的眼镜。尽管佩戴眼镜约三天，但她因双眼突然视力模糊而入住我们的门诊。在患者病史中发现使用过阿立哌唑。经验光仪测量，她双眼近视度数为-6.0屈光度；佩戴眼镜时双眼视力为6/10。患者的其他眼部检查结果正常。停用该药物并对患者进行随访。一个月后复查，患者双眼视力提高到10/10。测量的第一天Alx值比测量后一个月长0.3毫米；记录了其他眼前节检查结果的最小差异。虽然导致急性近视的具体机制尚未完全揭示，但可能是睫状肌痉挛、睫状体积液、周边葡萄膜积液以及眼部血清素能神经纤维的作用。我们认为这对临床医生很重要。他们在开具阿立哌唑处方时应牢记这些情况，并需要告知患者与眼睛相关的副作用。
