gltP基因的修订核苷酸序列，该基因编码大肠杆菌K-12的质子-谷氨酸-天冬氨酸转运蛋白。
Revised nucleotide sequence of the gltP gene, which encodes the proton-glutamate-aspartate transport protein of Escherichia coli K-12.
作者信息
Tolner B, Poolman B, Wallace B, Konings W N
机构信息
Department of Microbiology, University of Groningen, Haren, The Netherlands.
出版信息
J Bacteriol. 1992 Apr;174(7):2391-3. doi: 10.1128/jb.174.7.2391-2393.1992.
Abstract
The gene encoding the proton-glutamate carrier (GltP) of Escherichia coli K-12 was sequenced, and the primary structure of the protein was analyzed. The nucleotide sequence was found to differ in several aspects from the previously published sequence (B. Wallace, Y. Yang, J. Hong, and D. Lum, J. Bacteriol. 172:3214-3220, 1990). The corrected open reading frame encodes a protein of 437 (instead of 395) amino acids. Hydropathy analysis predicts 12 membrane-spanning alpha-helical regions. The complementary strand does contain an open reading frame possibly encoding a highly hydrophilic polypeptide of 272 amino acids.
摘要
对大肠杆菌K-12的质子-谷氨酸载体（GltP）编码基因进行了测序，并分析了该蛋白质的一级结构。发现该核苷酸序列在几个方面与先前发表的序列（B. 华莱士、Y. 杨、J. 洪和D. 卢姆，《细菌学杂志》172:3214 - 3220，1990年）不同。校正后的开放阅读框编码一个由437个（而非395个）氨基酸组成的蛋白质。亲水性分析预测有12个跨膜α螺旋区域。互补链确实包含一个开放阅读框，可能编码一个由272个氨基酸组成的高度亲水性多肽。
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