Casteilla L, Charrière G, Laharrague P, Cousin B, Planat-Benard V, Péricaud L, Chavoin J P
UMR 5018 CNRS UPS, IFR31, TSA 50032, IFR31, Bat. L1, CHU de Rangueil, 1, avenue Poulhès, 31059 Toulouse 09, France.
Ann Chir Plast Esthet. 2004 Oct;49(5):409-18. doi: 10.1016/j.anplas.2004.08.001.
The adipose tissue represents a large amount of adult tissue. For long time, it was considered as a filling tissue and used in plastic and reconstructive surgery. It was always studied for its main involvement in energy metabolism and energy disorders as diabetes and obesity. More recently, its endocrine functions emerged and thus play a key role in many physiological functions as inflammation and immunity. The presence of preadipocytes throughout life was demonstrated using primary culture technology from cells derived from adipose tissue. In recent papers, cells derived from adipose tissue were used for haematopoiesis, vascularisation or skeletal muscle recovery. Differentiation into functional cardiomyocytes, osteoblasts and neural cells was obtained in vitro. These spectacular data, the fact that adipose tissue is easy to sample and the possibility to create cell or tissue banks open numerous and promising perspectives in regenerative medicine.
脂肪组织是大量的成人组织。长期以来，它被视为一种填充组织，并用于整形和重建手术。人们一直在研究它主要参与能量代谢以及诸如糖尿病和肥胖症等能量紊乱的情况。最近，其内分泌功能得以显现，从而在许多生理功能如炎症和免疫中发挥关键作用。利用从脂肪组织中获取的细胞进行原代培养技术，证明了前脂肪细胞在整个生命过程中的存在。在最近的论文中，来自脂肪组织的细胞被用于造血、血管生成或骨骼肌恢复。在体外已实现向功能性心肌细胞、成骨细胞和神经细胞的分化。这些惊人的数据、脂肪组织易于取样的事实以及创建细胞或组织库的可能性，为再生医学开启了众多充满希望的前景。
