脂肪来源干细胞（ADSC）在整形和重建手术中的再生作用。
The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery.
机构信息
Reconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.
Welsh Centre for Burns & Plastic Surgery, ABMU Health Board, Swansea, UK.
出版信息
Int Wound J. 2017 Feb;14(1):112-124. doi: 10.1111/iwj.12569. Epub 2016 Feb 1.
Abstract
The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in plastic and reconstructive surgery. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. Adult mesenchymal stem cells appear to be an ideal stem cell population for practical regenerative medicine. Among these cells, adipose-derived stem cells (ADSC) have the potential to differentiate the mesenchymal, ectodermal and endodermal lineages and are easy to harvest. Additionally, adipose tissue yields a high number of ADSC per volume of tissue. Based on this background knowledge, the purpose of this review is to summarise and describe the proliferation and differentiation capacities of ADSC together with current preclinical data regarding the use of ADSC as regenerative tools in plastic and reconstructive surgery.
摘要
基于干细胞的疗法在修复和再生各种组织和器官方面具有潜在的应用价值，为整形和重建外科带来了范式转变。尽管这些细胞在理论上具有高度的益处，但由于法规和伦理考虑，胚胎干细胞（ESC）或诱导多能干细胞（iPSC）在临床情况下的应用受到限制。成人间充质干细胞似乎是实用再生医学的理想干细胞群体。在这些细胞中，脂肪来源的干细胞（ADSC）具有分化为间充质、外胚层和内胚层谱系的潜力，并且易于采集。此外，脂肪组织每单位组织的 ADSC 产量很高。基于这一背景知识，本综述的目的是总结和描述 ADSC 的增殖和分化能力，以及目前关于 ADSC 作为整形和重建外科再生工具的临床前数据。
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