Auffarth Gerd U, Holzer Mike P, Visessook Nithi, Apple David J, Völcker Hans E
Heidelberg IOL & Refractive Surgery Research Group, Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
J Cataract Refract Surg. 2004 Nov;30(11):2410-4. doi: 10.1016/j.jcrs.2004.03.039.
To investigate the removal times of ophthalmic viscosurgical devices (OVDs) with different intraocular lens (IOL) designs and materials.
Center for Research on Ocular Therapeutics and Biodevices, Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA, and Heidelberg IOL & Refractive Surgery Research Group, Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
In a standardized laboratory setup, the Miyake-Apple posterior view video technique was used to evaluate OVD removal from capsular bags in human autopsy eyes implanted with poly(methyl methacrylate) (PMMA), silicone, and acrylic IOLs. The cohesive OVD ProVisc (sodium hyaluronate 1.0%) and the dispersive OVD Viscoat (sodium hyaluronate 3.0% and chondroitin sulfate 4.0%) were stained with fluorescein for better visualization. The open-sky preparation and an Alcon Series 20000 Legacy phaco machine with a flow rate of 25 mL/min and a vacuum setting of +500 mm Hg (maximum irrigation/aspiration) were used. The time needed for complete removal of the cohesive and dispersive OVDs with each IOL type was measured and analyzed statistically.
The mean removal times for both OVDs were as follows: Alcon MZ60BD PMMA IOL-25.0 seconds +/- 3.7 (SD) (Viscoat), 15.9 +/- 6.9 seconds (ProVisc); Alcon AcrySof MA60BM IOL-35.5 +/- 10.0 seconds (Viscoat), 25.6 +/- 4.7 seconds (ProVisc); Chiron/Bausch & Lomb C1043 silicone IOL-46.5 +/- 10.5 seconds (Viscoat), 17.3 +/- 2.1 seconds (ProVisc); AMO SI-30 silicone IOL-33.5 +/- 3.1 seconds (Viscoat), 15.3 +/- 6.3 seconds (ProVisc); and Pharmacia 912 silicone IOL-18.3 +/- 5.8 seconds (Viscoat), 19.8 +/- 4.3 seconds (ProVisc).
Differences in OVD removal times were detected. The removal time for the cohesive OVD correlated with the IOL material. Overall, the time needed for complete removal was significantly longer for the dispersive OVD than for the cohesive OVD.
研究不同人工晶状体（IOL）设计和材料的眼科粘弹剂（OVD）的清除时间。
美国南卡罗来纳州查尔斯顿市南卡罗来纳医科大学风暴眼研究所眼科眼部治疗与生物设备研究中心，以及德国海德堡鲁普雷希特 - 卡尔斯大学眼科海德堡IOL与屈光手术研究组。
在标准化实验室设置中，采用三宅 - 苹果后视图视频技术，评估在植入聚甲基丙烯酸甲酯（PMMA）、硅胶和丙烯酸酯IOL的人类尸眼囊袋中OVD的清除情况。将粘性OVD ProVisc（1.0%透明质酸钠）和分散性OVD Viscoat（3.0%透明质酸钠和4.0%硫酸软骨素）用荧光素染色以更好地观察。采用开放式制备以及流速为25 mL/min、真空设置为+500 mmHg（最大冲洗/抽吸）的爱尔康20000型Legacy超声乳化仪。测量并统计分析每种IOL类型完全清除粘性和分散性OVD所需的时间。
两种OVD的平均清除时间如下：爱尔康MZ60BD PMMA IOL - Viscoat为25.0秒±3.7（标准差），ProVisc为15.9±6.9秒；爱尔康AcrySof MA60BM IOL - Viscoat为35.5±10.0秒，ProVisc为25.6±4.7秒；Chiron/博士伦C1043硅胶IOL - Viscoat为46.5±10.5秒，ProVisc为17.3±2.1秒；AMO SI - 30硅胶IOL - Viscoat为33.5±3.1秒，ProVisc为15.3±6.3秒；辉瑞912硅胶IOL - Viscoat为18.3±5.8秒，ProVisc为19.8±4.3秒。
检测到OVD清除时间存在差异。粘性OVD的清除时间与IOL材料相关。总体而言，分散性OVD完全清除所需时间显著长于粘性OVD。
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