Choi Gordon, Gomersall Charles D, Lipman Jeff, Wong April, Joynt Gavin M, Leung Patricia, Ramsay Sarah J, Ho Oi Man
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Int J Antimicrob Agents. 2004 Nov;24(5):468-72. doi: 10.1016/j.ijantimicag.2004.06.005.
We studied an in vitro model of continuous venous-venous haemofiltration (CVVH), into which levofloxacin 100 mg was infused, to determine levofloxacin adsorption and to determine the effect of filter material and point of dilution (pre- or post-filter) on sieving coefficient. Mean (standard deviation; S.D.) adsorption was 18.7 (5.3) mg for the polyamide filter and 40.2 (2.0) mg for the polyacrylonitrile (PAN) filter (P < 0.001). Post-dilution resulted in a minor, but statistically significant, decrease in sieving coefficient (pre-dilution 0.96 (S.D. 0.10), post-dilution 0.88 (S.D. 0.11) with the PAN filter. These data indicate that the variability in published values for levofloxacin sieving coefficient are not due to variation in point of dilution or membrane type (PAN or polyamide). Significant adsorption of levofloxacin onto PAN filters occurs.
我们研究了一种连续静脉-静脉血液滤过（CVVH）的体外模型，向其中输注100 mg左氧氟沙星，以测定左氧氟沙星的吸附情况，并确定滤器材料和稀释点（滤器前或滤器后）对筛系数的影响。聚酰胺滤器的平均（标准差；S.D.）吸附量为18.7（5.3）mg，聚丙烯腈（PAN）滤器的平均吸附量为40.2（2.0）mg（P < 0.001）。对于PAN滤器，稀释后筛系数略有下降，但具有统计学意义（稀释前为0.96（S.D. 0.10），稀释后为0.88（S.D. 0.11））。这些数据表明，已发表的左氧氟沙星筛系数值的差异并非由于稀释点或膜类型（PAN或聚酰胺）的变化所致。左氧氟沙星在PAN滤器上有显著吸附。
