Yu Y-Q, Tao R, Wei J, Xu Q, Liu S-Z, Ju G-Z, Shi J-P, Zhang X, Xie L, Shen Y
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, China.
Prostaglandins Leukot Essent Fatty Acids. 2004 Dec;71(6):405-8. doi: 10.1016/j.plefa.2004.09.001.
The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.
本研究旨在在中国人群中复制PTGS2/PLA2G4A基因座与精神分裂症之间的关联。我们招募了168个汉族血统的中国亲子三联体，由父亲、母亲和患有精神分裂症的患病后代组成。在对3个信息性单核苷酸多态性（SNP）进行基因分型后，没有一个显示出与精神分裂症的等位基因关联；单倍型分析也未能发现与该疾病的单倍型关联。由于与最初显示PTGS2/PLA2G4A基因座与精神分裂症之间存在遗传关联的英国人群相比，所分析的SNP的等位基因和基因型频率在中国人群中有所不同，种族背景可能是最初发现难以复制的主要原因。
